Dopamine neurons in the ventral periaqueductal gray modulate isoflurane anesthesia in rats
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چکیده
منابع مشابه
Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter.
Recent evidence suggests that dopamine plays an important role in arousal, but the location of the dopaminergic neurons that may regulate arousal remains unclear. It is sometimes assumed that the dopaminergic neurons in the ventral tegmental area that project to the prefrontal cortex and striatum may regulate the state of arousal; however, the firing of these dopaminergic neurons does not corre...
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Despite the central role of general anesthesia in modern healthcare, the frequency of anesthesia-related morbidity resulting from the toxicity and non-specificity of anesthetic drugs remains high. Among the key behavioral states of general anesthesia is antinociception (reduced sensitivity to pain). Within the nociceptive pathway in the brain and the central nervous system, the periaqueductal g...
متن کاملEbf2 is required for development of dopamine neurons in the midbrain periaqueductal gray matter of mouse.
Dopaminergic (DA) neurons in the midbrain ventral periaqueductal gray matter (PAG) play critical roles in various physiological and pathophysiological processes including sleep-wake rhyme, antinociception, and drug addiction. However, the molecular mechanisms underlying their development are poorly understood. Here, we showed that PAG DA neurons arose as early as E15.5 in mouse embryos. During ...
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Freezing, a characteristic pattern of defensive behavior elicited by fear, is associated with a decrease in the heart rate. Central mechanisms underlying fear bradycardia are poorly understood. The periaqueductal gray (PAG) in the midbrain is known to contribute to autonomic cardiovascular adjustments associated with various emotional behaviors observed during active or passive defense reaction...
متن کاملDopamine receptors in the ventral tegmental area modulate male sexual behavior in rats.
The mesocorticolimbic dopamine tract is considered to be a substrate for motivation and reward as well as for locomotor behavior. The present experiments assessed the role of dopamine cell bodies in the ventral tegmental area (VTA), the source of this tract, in the copulatory behavior of male rats. The dopamine agonist apomorphine or the dopamine antagonist cis-flupenthixol were microinjected i...
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ژورنال
عنوان ژورنال: CNS Neuroscience & Therapeutics
سال: 2020
ISSN: 1755-5930,1755-5949
DOI: 10.1111/cns.13447